Registration Dossier
Registration Dossier
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EC number: 208-060-1 | CAS number: 506-93-4
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: not reported
- Principles of method if other than guideline:
- Measurement of pH of 0.1M solution of Guanidine nitrate and calculation of pKb.
- GLP compliance:
- no
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- ca. 10.2
- Temp.:
- 25 °C
- Conclusions:
- In the peer-reviewed document the dissociation constant of the conjugate base of Guanidine nitrate is reported to be Kb = 1.51x10E-4 and the hydrolysis constant Kh = 6.75x10E-11 (25 °C).
pKa = 10.2 (calculated with pKa+pKb=14) - Executive summary:
In the peer-reviewed document the dissociation constant of the conjugate base of Guanidine nitrate is reported to be Kb = 1.51x10E-4 and the hydrolysis constant Kh = 6.75x10E-11 (25 °C).
pKa = 10.2 (calculated with pKa+pKb=14)
Reference
Measured pH: 5.58 with 0.1M Guanidinium nitrate, calculated Kb named in publication: 1.51 Exp-4
pKa calculated with pKa+pKb=14
Description of key information
The calculated pKa of Guanidine Nitrate is 10.2.
Key value for chemical safety assessment
- pKa at 20°C:
- 10.2
Additional information
In the peer-reviewed document of Carignan and Satriana (1967) the dissociation constant of the conjugate base of Guanidine nitrate is reported to be Kb = 1.51x10E-4 and the hydrolysis constant Kh = 6.75x10E-11 (25 °C). The calculated pKa is 10.2 (calculated with pKa+pKb=14).
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