Cyanamide

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.01 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.032 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.001 mg/L

Assessment factor:

100

Extrapolation method:

assessment factor

PNEC marine water (intermittent releases):

0.003 mg/L

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

88 mg/L

Assessment factor:

1

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.04 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.004 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.151 mg/kg soil dw

Assessment factor:

10

Extrapolation method:

assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

PNEC oral

PNEC value:

0.5 mg/kg food

Assessment factor:

300

Conclusion on classification

Classification-related information

Hydrolysis: hydrolytically stable at pH values of 5, 7 and 9 at 25 °C

Biodegradation: readily biodegradable

Log Pow: - 0.72

 

Ecotoxicological data

Test data on short-term (acute) toxicity

Fish, short-term, freshwater: LC50 (96 h) = 43.1 mg /L (EPA-660/3-75-009, L. macrochirus; McAllister, 1985)

Invertebrates, short-term, freshwater:  EC50 = 3.2 mg a.i./L (OECD 202, D. magna; Adema, 1983)

Algae (green algae), freshwater:  EC50 (72 h, growth rate) = 14.7 mg a.i/L (similar OECD 201, P. subcapitata; Seyfried, 2000)

Aquatic plants, freshwater: EC50 (7 d, growth rate) = 5.61 mg a.i./L (OECD 221, L. gibba; Hertl, 2000)

 

Test data on long-term (chronic) toxicity

Fish, long-term, freshwater: NOEC (21 d) = 3.7 mg/L (OECD 204, O. mykiss; Bowman, 1990)

Invertebrates, long-term, freshwater: NOEC (21 d) = 0.1044 mg/L (EPA OPP 72-4, D. magna; Murrell, 1995)

Algae, freshwater:  NOEC (72 h, growth rate) = 2.6 mg a.i/L (similar OECD 201, P. subcapitata; Seyfried, 2000)

Aquatic plants, freshwater: NOEC (7 d, growth rate) = 5.61 mg a.i./L (OECD 221, L. gibba; Hertl, 2000)

 

Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. The substance is readily biodegradable and has a log Pow of  -0.72. For short-term toxicity Daphnia magna has been evaluated to be the most sensitive species with an acute EC50 of 3.2 mg/L. The 96-hour LC50 for fish was determined to be = 43.1 mg a.i. /L. In a study similar to OECD 201 with the standard test organism Pseudokirchneriella subcapitata the 72-hour ErC50 and NOEC (growth rate) of the substance was determined to be 28.8 mg/L (nominal, corresponding to 14.7 mg a.i./L) and 5.0 mg/L (nominal, corresponding to 2.6 mg a.i./L), respectively. In a study with the blue-green algae Anabaena flos-aquae (Hertl, 2000) EC50 values below 1 mg/L were determined. However, the study is regarded not valid due to major methodological deficiencies and is hence not considered for the hazard and risk assessment. The lowest long-term result was obtained for Daphnia magna. The 21-day NOEC was found to be 2.6 mg a.i/L. Based on available data, the substance is not classified and labelled for aquatic short-term (acute) toxicity, but as long-term (chronic) toxicity category 3 (H412, “Harmful to aquatic life with long-lasting effects”; based on the long-term result for D. magna) according to Regulation (EC) No 1272/2008 (CLP), , as amended for the eighteenth time in Regulation (EU) 2022/692.