Registration Dossier
Registration Dossier
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EC number: 237-430-5 | CAS number: 13780-39-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Bioaccumulation study on titanium oxychloride is technically not feasible as the substance is highly unstable in aqueous environment in the environmentally relevant pH range. Thus read across from final hydrolysis product titanium dioxide is being proposed. Studies on titanium dioxide show a little tendency to accumulate in organisms. The BCF of 352 L/kg ww is not relevant for classification purposes nor triggering PBT assessment.
Key value for chemical safety assessment
- BCF (aquatic species):
- 352 L/kg ww
Additional information
No experimental data on bioaccumulation can be obtained experimentally on both parent compound titanium tetrachloride or target compound titanium oxychloride, as the hydrolysis reaction from titanium tetrachloride via titanium oxychloride to hydrogen chloride (CAS 7647-01-0) and to titanium dioxide (CAS 13463-67-7) proceeds in aqueous environment completely and rapidly (half-life below 0.1 min). Therefore read across from final hydrolysis product titanium dioxide is being proposed. Experimental investigation on titanium dioxide (Frederici et al 2007) revealed enrichment of undefined titanium species in fish. The higher the medium concentration the lower was the measured BCF. About 352 L/kg ww was established for low concentrations (0.1 mg/L) and lipid-rich organs, while about 272 L/kg ww in steady state was found for muscles (lower in gills). As due to the experimental set-up (measurement at days 7 and 14 only) no equilibrium was detectable, further enrichment in lipid-rich tissues can not be excluded. Nonetheless the experimental data do not raise concerns with regard to bioaccumulation, as the BCF of 352 L/kg ww is not relevant for classification purposes nor triggering PBT assessment.
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