Silicon tetrachloride

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

No data

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

Test conducted prior to guideline adoption

Deviations:

yes

Remarks:

No test substance or animal environmental condition details.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Silicon tetrachloride

EC Number:

233-054-0

EC Name:

Silicon tetrachloride

Cas Number:

10026-04-7

Molecular formula:

Cl4Si

IUPAC Name:

tetrachlorosilane

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 25 % in corn oil
- Amount of vehicle: No data
- Justification for choice of vehicle: No data
- Purity: No data

Doses:

158, 200, 251 and 316 mg/kg bw

No. of animals per sex per dose:

Five animals per dose (some doses had two male and three female, others had three male and two female)

Control animals:

no

Details on study design:

- Duration of observation period following administration: At least 8 days (animals died up to day 8, but no other information).
- Frequency of observations and weighing: Observations for clinical signs of toxicity were made - no further details given.
- Necropsy of survivors performed: no
- Other examinations performed: macroscopic examination of animals that died.

Statistics:

Mortality data was used for calculation of the LD50 and was done according to modification of the method of EJ de Beer.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

238 mg/kg bw

95% CL:

> 205 - < 275

Mortality:

There were 0, 1, 4 and 4 deaths in the 158, 200, 251 and 316 mg/kg bw. Survival time was several hours to eight days with most deaths occurring in four to eight days.

Clinical signs:

other: Symptoms included prostration and dyspnea in 30 minutes. Severe diarrhea and loss of appetite were noted.

Gross pathology:

Severe inflammation of the gastric mucosa was noted. The intestinal tract was gaseous and irritated. Liver and renal congestion was noted.

Other findings:

No other findings reported

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

In the acute oral toxicity study, conducted according to a protocol similar to the now-delete OECD Test Guideline 401 and pre-GLP, an LD50 for silicon tetrachloride was concluded to be 238 mg/kg bw in rats.