Registration Dossier
Registration Dossier
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EC number: 211-074-0 | CAS number: 629-11-8
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Internal BASF method was used (inhalation risk test), which was in large part equivalent to OECD guideline 403
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Hexane-1,6-diol
- EC Number:
- 211-074-0
- EC Name:
- Hexane-1,6-diol
- Cas Number:
- 629-11-8
- Molecular formula:
- C6H14O2
- IUPAC Name:
- hexane-1,6-diol
- Details on test material:
- - Name of test material (as cited in study report): Hexandiol-1,6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: mean 144 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for 8 hours
- Temperature in air chamber: 100°C - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- 3.3 mg/l (5.4 g substance loss during test)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 3.3 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: 100 °C
- Mortality:
- no deaths occured
- Clinical signs:
- other: no effects
- Gross pathology:
- no abnormalities found
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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