Registration Dossier
Registration Dossier
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EC number: 248-666-3 | CAS number: 27813-02-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Limited no. of animals; short duration of study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Methacrylic acid, monoester with propane-1,2-diol
- EC Number:
- 248-666-3
- EC Name:
- Methacrylic acid, monoester with propane-1,2-diol
- Cas Number:
- 27813-02-1
- Molecular formula:
- C7H12O3
- IUPAC Name:
- 1-hydroxypropan-2-yl 2-methylprop-2-enoate; 2-hydroxypropyl 2-methylprop-2-enoate
- Reference substance name:
- Methacrylic acid monoester with 1,2-propandiol
- IUPAC Name:
- Methacrylic acid monoester with 1,2-propandiol
- Details on test material:
- TS-Freetext:
Purity: 98.6 %
Inhibitor: 200 ppm Hydroquinone
The substance tested consists of a isomeric mixture ca. 20 %
2-Propenoic acid, 2-methyl, 2-hydroxy-1-methylethylester and
ca. 80 % 2-Propenoic acid, 2-methyl, 2-hydroxypropylester
(Cas: 923-26-2).
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 1 week
- Frequency of treatment:
- 6 alternate 24 hour application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
undiluted material, occlusive
Basis:
- Control animals:
- other: no data specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
Neither local nor systemic ill-effects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
