Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-550-6 | CAS number: 84-66-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: A review presented at the Society of Toxicology's 13th annual meeting Washington DC USA 1974 before the introduction of OECD guidelines and GLP
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- A review paper presented more than 30 years ago with limited details of methodology and before the introduction of OECD guidelines & GLP.
Groups of 10 male ICR mice received undiluted DEP via the intraperitoneal route and were then observed for 7 days. - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl phthalate
- EC Number:
- 201-550-6
- EC Name:
- Diethyl phthalate
- Cas Number:
- 84-66-2
- Molecular formula:
- C12H14O4
- IUPAC Name:
- .
- Details on test material:
- Supplied by Eastman Chemicals Kingsport Tennessee USA
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- None
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- Single ip dose
- Doses:
- Not reported
- No. of animals per sex per dose:
- 10 males
- Control animals:
- not specified
- Details on study design:
- No details
- Statistics:
- The LD50, 95% confidence limits & slope were calculated from the 7 day mortality data by Cornfield and Mantel's (1950) modification of Karber's method as described in Some new aspects of the application of maximum liklihoodto the calculation of the dosage response curve. Amer Statist Assoc J 45, pp 181-210 1950
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.22 other: g/kg bw
- Based on:
- test mat.
- 95% CL:
- > 2.86 - < 3.62
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2.87 mL/kg bw
- Based on:
- test mat.
- Mortality:
- Not reported
- Clinical signs:
- Not reported
- Body weight:
- Not reported
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Any other information on results incl. tables
The LD50 value (3.22 g/kg) compares well with values obtained by other investigators, Calley et al (2.83 g/kg) & Fassett (2.8 g/kg).
Calley D, Autian J & Guess WL Toxicology of a series of phthalate esters. J Pharm Sci 55 pp 158 -162 1966
Fassett DW, Esters in Industrial Hygeine and Toxicology, Patty FA editor Vol 2 pp 1902 -1910 1963
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
