Registration Dossier
Registration Dossier
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EC number: 406-860-7 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 March 1990 to 14 January1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Product designation: Monoazo Yellow BG 3247
Identification: FAT 40400/A BG 3247/TV 6 - Analytical method:
- photometric method
- Type:
- log Pow
- Partition coefficient:
- ca. -10
- Remarks on result:
- other: Calculated value
- Details on results:
- The preliminary experiment gave the following concentrations: octanol < 8E-8 mol/L and water 3.7E-4 mol/L, yielding a log P<-3.67. This value showed that the expected Pow lies outside the range of the flask shaking method and must be estimated by the calculation method.
- Conclusions:
- The calculated partition coefficient (log Pow) of FAT 40400/A between n-octanol and aqueous phase is ca. -10.
- Executive summary:
In a GLP-compliant study, performed according to the OECD guideline 107, the shaking flask method was used to determine the partition coefficient of the test substance between n-octanol and aqueous phase. However, it was shown that the Pow could not be determined and had to be estimated by using the calculation method described in OECD guideline 117. So, based on the study results, the calculated partition coefficient (log Pow) of the test substance was estimated to be ca. -10.
Reference
Description of key information
In a GLP-compliant study, performed according to the OECD guideline 107, the shaking flask method was used to determine the partition coefficient of the test substance between n-octanol and aqueous phase. However, it was shown that the Pow could not be determined and had to be estimated by using the calculation method described in OECD guideline 117. So, based on the study results, the calculated partition coefficient(log Pow)of the test substance was estimated to be ca. -10.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -10
- at the temperature of:
- 25 °C
Additional information
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