Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 241-234-5 | CAS number: 17194-00-2
Carcinogenicity
Administrative data
Description of key information
According to the NTP study performed 1994, the concentration of 2500 ppm represents a NOAEL for carcinogenicity (corresponding to Ba doses of 60 and 75 mg/kg bw/d to male and female rats, respectively, and 160 and 200 mg/kg bw/d to male and female mice, respectively). Based on this value the NOAEL for Ba(OH)2 is calculated at 75 mg/kg bw/day.
Key value for chemical safety assessment
Justification for classification or non-classification
There was no evidence of carcinogenic activity (showing no chemical related increase of malignant or benign neoplasms) of barium chloride in both sexes of rats and mice that received 500, 1250, and 2500 ppm. Thus, the concentration of 2500 ppm represents a NOAEL (corresponding to barium doses of 60 and 75 mg/kg bw/d to male and female rats, respectively, and 160 and 200 mg/kg bw/d to male and female mice, respectively). No classification of the substance as CMR substance is required.
Additional information
Read across BaCl2*2H2O to Ba(OH)2:
The toxicity of barium hydroxide and barium chloride may reasonably be considered to be determined by availability of Ba2+cations. As a first surrogate for bioavailability, the water solubility of a test substance may be used. Barium chloride is highly water soluble with ca. 263 g/L at pH ca. 6.5 (510.4 g/L at pH 1.5). Also the water solubility of barium hydroxide is high (37.4 mg/L at pH > 13). Hence, any read across from barium chloride to barium hydroxide is considered to be justified and will likely lead to rather conservative no-effect levels.It is noted; although Ba(OH)2is a strong base (pH 13 for a 10% solution) it will be neutralised within the gastrointestinal tract (pH approx. 1.5 - 2).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
