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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report that meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Other (1981). The method employed in the testing, evaluation, and the scoring of the results was adopted from the U.S. Federal Hazardous Substances Act Regulations study guidelines, 16 CFR, section 1500.3. [Comparable to OECD Test Guideline 401].
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Reaction products of triphenyl phosphite and isodecanol (1:2)
EC Number:
701-374-4
Cas Number:
25550-98-5
Molecular formula:
C26H47O3P
IUPAC Name:
Reaction products of triphenyl phosphite and isodecanol (1:2)
Details on test material:
- Name of test material (as cited in study report): Diisodecyl phenyl phosphite
- Lot/batch No.: PDDP-002-03240A
- Commercial, purity: Not stated (Phosphorus content = 7.09%)
- Supplier: Borg Warner Company, Parkersburg, WV

Test animals

Species:
rat
Strain:
other: Sherman-Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 and 300 grams
- Fasting period before study: Animals were fasted overnight prior to dosing, but were not deprived of water.
- Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR, Part 3.
- Diet: Following administration the animals were allowed food ad libitum
- Water: Following administration the animals were allowed water ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
The sample was dosed as supplied (described as a colorless to straw-colored liquid).
Doses:
5 g/kg
No. of animals per sex per dose:
5
Control animals:
other: Used for data submission
Details on study design:
- Duration of observation period following administration: 21 days
- The animals were observed daily for signs of toxicity and mortality.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD0
Effect level:
5 other: g/kg
Remarks on result:
other: no deaths
Mortality:
No animals died during the experiment
Clinical signs:
other: After 1 hour the animals (number not specified) appeared slightly depressed and ruffled. After 24 hours the animals appeared to improve and within 48 hours the animals were essentially normal.
Gross pathology:
Gross pathological examination revealed no remarkable findings.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
No deaths occurred at 5 g/kg body weight, the LD0 = 5 g/kg bw, the LD50 > 5 g/kg/
Executive summary:

No deaths occurred at highest dose of 5 g/kg.