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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-404-7 | CAS number: 106-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
- Principles of method if other than guideline:
- The mutagenic potency of the test substance in Tradescantia was examined.
- GLP compliance:
- no
Test material
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- yes
- Details on preparation and application of test substrate:
- Vehicle: 0.2 M citrate-phosphate buffer (pH = 5)
Test substance purchased from Sigma Chemical Co. (St. Louis, MO, USA)
Test organisms
- Species:
- other: Tradescantia clone 4430
- Details on test organisms:
- Hybrid of T. subacaulis X T. hirsutiflora cultivated at the Institute of Experimental Botany, Prague
Study design
- Test type:
- other: Mutagenicity assay
- Study type:
- laboratory study
- Total exposure duration:
- 15 d
- Post exposure observation period:
- Mutations scored on days 9-14 post-exposure
Test conditions
- Nominal and measured concentrations:
- 0 (citrate phosphate buffer only), 25, 50, 100, 125, 150 and 200 mM
Results and discussion
Effect concentrations
- Species:
- other: Tradescantia
- Dose descriptor:
- other: mutagenic potency
- Effect conc.:
- 0.46 other: stamen hair mutants/µmole.
Any other information on results incl. tables
A significant increase in pink stamen hair mutations was seen only in the 125 and 150 mM treatment groups. The test substance was found to be toxic at concentrations above 150 mM, and repressed flowering. At 150 mM, the test substance induced a 3-fold increase in the mutant frequency over the spontaneous control.
Applicant's summary and conclusion
- Conclusions:
- Under the test conditions employed in this study, the test substance was found to be mutagenic in Tradescantia clone 4430 stamen hair cells when compared to the control. The mutagenic potency of the test substance in Tradescantia was 0.46 stamen hair mutants/µmole.
- Executive summary:
The test substance was tested in a mutagenic assay in plants at concentrations of 0 (citrate phosphate buffer only), 25, 50, 100, 125, 150, and 200 mM. A significant increase in pink stamen hair mutations was seen only in the 125 and 150 mM treatment groups. The test substance was found to be toxic at concentrations above 150 mM, and repressed flowering. At 150 mM, the test substance induced a 3-fold increase in the mutant frequency over the spontaneous control. Under the test conditions employed in this study, the test substance was found to be mutagenic in Tradescantia clone 4430 stamen hair cells when compared to the control. The mutagenic potency of the test substance in Tradescantia was 0.46 stamen hair mutants/ µmole.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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