Registration Dossier
Registration Dossier
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EC number: 619-447-3 | CAS number: 99607-70-2
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-10-23 - 1996-10-23 (experimental phase)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 3.55
- Temp.:
- 20 °C
- Remarks on result:
- other: (basic dissociation constant)
- Conclusions:
- The study is considered to be adequate and reliable.
- Executive summary:
pKa at 20 °C: 3.55 (basic dissociation constant)
In aqueous solution the neutral from of the substance is predominantly present at pH >3.55, the protonic form at pH 3.55.
Reference
Extrapolated from measurements in water with 20, 30 and 40 % ethanol, since the test substance is only sparingly soluble in water.
In aqueous solution the neutral from of the substance is predominantly present at pH >3.55, the protonic form at pH <3.55.
Description of key information
pKa (Jäkel, 20 °C, basic): 3.55
Key value for chemical safety assessment
- pKa at 20°C:
- 3.55
Additional information
A guideline study is available which is considered to be reliable and adequate, and is carried forward for use in risk assessment, classification and labelling.
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