Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 233-032-0 | CAS number: 10024-97-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
As N2O is a gas, sensitisationviaskin is not considered relevant. Furthermore, the wealth of available human data on N2O does not indicate that the substance is a skin sensitiser.
Justification for selection of skin sensitisation endpoint:
Study scientifically unjustified. N2O is a gas and as such the route of exposure is not relevant
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
Markers of respiratory sensitisation are manifest in the form of respiratory reactions including asthma, rhinitis and alveolitis. From the animal data available there is no evidence to suggest that N2O is a respiratory sensitiser. Such studies confirm that N2O effects the respiratory system via depression of the ventilatory response in the presence of hypoxia, rather than one of sensitisation.
Justification for selection of respiratory sensitisation endpoint:
Currently no validated in vivo methods available.
Justification for classification or non-classification
As N2O is a gas, skin sensitisation is unlikely to be a relevant endpoint. Whilst no in vivo respiratory sensitisation data exist, N2O reacts directly with methionine synthase (MS) and therefore is unlikely to have any direct effects on acute pulmonary function / lung tissue. The effects seen following exposure to N2O are attributed to the dilution of oxygen from inhaled air, causing hypoxia, rather than lung targeted toxicity. Therefore,N2O has not been classified as a skin or respiratory sensitiser and no classification is therefore required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
