Registration Dossier
Registration Dossier
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EC number: 205-793-9 | CAS number: 151-56-4
Endpoint summary
Administrative data
Description of key information
Ethylenimine was found to be corrosive to both skin and eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
There are no human data on irritation / corrosion of ethyleneimine available.
In skin irritation / corrosion tests all animals died within 24 hours after application of the undiluted test substance for 1, 5, and 15 min. Based upon the observed findings, ethylenimine can be estimated to be corrosive and very toxic by skin contact (BASF AG, 1961).
Application of 0.05 mL of the undiluted test substance in the eye of rabbits caused corrosion of the cornea and death of the animals. Renal injuries (proteins, erythrocytes, leukocytes and renal epithelium in the urine, increase of blood urea, renal papillary necrosis) characteristic for the test substance were observed after application of the substance to the eye of rabbits (BASF AG 1965).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
According to Annex I of Directive 67/548/EEC, the substance is classified as C; R34.
According to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, the classification is H314, Cat. 1B and H318, Cat. 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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