Registration Dossier
Registration Dossier
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EC number: 202-473-0 | CAS number: 96-05-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source).
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Structure-activity Relationships in the Hydrolysis of Acrylate and Methacrylate Esters by Carboxylesterase In Vitro.
- Author:
- McCarthy, T.J. and Witz, G.
- Year:
- 1 997
- Bibliographic source:
- Toxicol., 116: 153-158; cited in OECD SIDS IUCLID data set (06.05.2009)
Materials and methods
- Objective of study:
- other: hydrolysis
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase was tested in vitro.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl methacrylate
- EC Number:
- 201-297-1
- EC Name:
- Methyl methacrylate
- Cas Number:
- 80-62-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- methyl methacrylate
- Test material form:
- other: liquid
Constituent 1
- Radiolabelling:
- no
Results and discussion
Any other information on results incl. tables
Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase in vitro:
| Esters | Km (µM) | Vmax (nmol/min) |
| Ethyl acrylate | 134 +/- 16.8 | 9 +/- 2.0 |
| Ethyl methacrylate | 159 +/- 90 | 5.2 +/- 2.5* |
| Butyl acrylate | 33 +/- 8.5* | 1.5 +/- 0.8* |
| Butyl methacrylate | 72 +/- 28* | 1.8 +/- 0.6* |
| Ethyleneglycol dimethacrylate | 64 +/- 24* | 6.9 +/- 2.4 |
| Tetraethyleneglycol dimethacrylate | 39 +/- 15* | 2.9 +/- 1.0* |
* Significantly different (p < 0.05) from ethyl acrylate
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
