Registration Dossier
Registration Dossier
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EC number: 618-561-0 | CAS number: 9046-10-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-07-28 to 2005-12-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Limited data on purity and stability, pH not reported
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- yes
- Remarks:
- No data on purity or stability of test substance; pH not reported.
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- yes
- Remarks:
- Statement, no certificate
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Name as cited in study report: Jeffamine D-230
- Substance type: Active
- Color: colorless
- Lot/Batch number: 4W512
- Test substance receipt: received 2005-07-05 727.9 g, received 2005-07-13 750.9 g
- Analytical Purity: 100% - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 1.34
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not reported
- Type:
- Pow
- Partition coefficient:
- 22.09
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- Over all three replicates, the log Pow ranged from 1.25 to 1.39.
- Conclusions:
- The partition coefficient (Pow) of the test substance was determined to be 22.09 with a log Pow of 1.34, by reverse phase HPLC estimation.
Reference
Results for reference substances
Compound | Mean retention time (tr) | k | Log k | Theoretical Log Pow | Calculated Log Pow |
| Thiourea | 1.638 | 0.0000 | NA | NA | NA |
| Trichloroethylene | 4.691 | 1.8631 | 0.270230 | 2.4 | 2.60 |
| Toluene | 5.115 | 2.1221 | 0.326761 | 2.7 | 2.79 |
| Naphthalene | 6.406 | 2.9099 | 0.463873 | 3.6 | 3.27 |
| Phenanthrene | 12.170 | 6.4281 | 0.808081 | 4.5 | 4.47 |
| DDT | 36.475 | 21.2637 | 1.327638 | 6.2 | 6.27 |
Statistics:
- Slope: 3.475685
- Intercept: 1.658
- Correlation: 0.99133
Results for test substances
| Total area | k | Log k | Calculated Log Pow | |
| Replica 1 | 10825169 | 0.764 | -0.117 | 1.25 |
| Replica 2 | 12014568 | 0.839 | -0.076 | 1.39 |
| Replica 3 | 10379521 | 0.834 | -0.079 | 1.38 |
| Average k | 0.812 |
| Log k | -0.0903 |
| Log Pow | 1.34 |
| Pow | 22.09 |
Description of key information
The partition coefficient (Pow) of the test substance was determined to be 22.09 with a log Pow of 1.34 at 25 °C by reverse phase HPLC estimation (Stillmeadow Inc., 2005).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.34
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
