Registration Dossier
Registration Dossier
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EC number: 204-873-0 | CAS number: 127-95-7
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- January 1986 - July 1987
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The study is not according to an international accepted guideline, nor is any data available on GLP. The study is described in a publication which provides very limited information on used methods, performance and raw data.
Data source
Reference
- Reference Type:
- publication
- Title:
- Fussruckenekzeme infolge von Ledersensibilirierung
- Author:
- Gehring, W., Gloor, M., Gehse, M.
- Year:
- 1 988
- Bibliographic source:
- Fortschr. Med. Vol 106 Nr 3 pp 45 - 46
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- not specified
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 26 patients with sympthoms of eczema on the dorsum of the foot were tested for sensitizing responses after application of several substances used in the manufacture of leather (tanning and dyeing agents), including oxalic acid. No details on the used method were included in the report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Oxalic acid
- EC Number:
- 205-634-3
- EC Name:
- Oxalic acid
- Cas Number:
- 144-62-7
- IUPAC Name:
- oxalic acid
- Details on test material:
- - Name of test material (as cited in study report): Oxalsäure
- Physical state: liquid (solution in water)
Constituent 1
Method
- Type of population:
- general
- Controls:
- No data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- SYMPTOMS
- Frequency, level, duration of symptoms observed:
No data
NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions: 14 (n = 26)
- Number of subjects with negative reactions no data
- Number of subjects with equivocal reactions no data
- Number of subjects with irritating reactions no data
RESULT OF CASE REPORT:
no data
OTHER RESULTS:
no data
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the test oxalic acid is found to be a relevant allergen.
- Executive summary:
In skin testing of patients with eczema of the dorsum of the foot, allergens used in the manufacture of leather as tanning and dyeing agents, were applied. It was seen that potassium dichromate has no particular significance. Oxalic acid and phenylhydrazine, present in traces in leather dyes, as also dinitrochlorbenzene are all equally potent sensitizing agents.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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