Registration Dossier
Registration Dossier
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EC number: 278-758-9 | CAS number: 77745-66-5
Endpoint summary
Administrative data
Description of key information
Data show slight irritation to the skin and eye, which is fully reversible and below the level of classification.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
New testing (Lowe 2014) on TiTDP indicates that it is not a skin and eye irritant. TiTDP was only slightly irritating to the skin and mildly irritating to the eye. These results are similar to those of triisodecyl phosphite (TDP), which is also not a skin and eye irritant, supporting the case that these phosphites have similar mammalian toxicity profiles (see Justification in Section 13).
Justification for selection of skin irritation / corrosion endpoint:
New testing (Lowe 2014) on TiTDP indicates that it is not a skin and eye irritant. TiTDP was only slightly irritating to the skin and mildly irritating to the eye. These results are similar to those of triisodecyl phosphite (TDP), which is also not a skin and eye irritant, supporting the case that these phosphites have similar mammalian toxicity profiles (see Justification in Section 13).
Justification for selection of eye irritation endpoint:
New testing (Lowe 2014) on TiTDP indicates that it is not a skin and eye irritant. TiTDP was only slightly irritating to the skin and mildly irritating to the eye. These results are similar to those of triisodecyl phosphite (TDP), which is also not a skin and eye irritant, supporting the case that these phosphites have similar mammalian toxicity profiles (see Justification in Section 13).
Justification for classification or non-classification
Results from new GLP guideline studies shows slight to mild skin and eye irritation, well below the level of classification.
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