7-oxabicyclo[4.1.0]hept-3-ylmethyl 7-oxabicyclo[4.1.0]heptane-3-carboxylate

Short-term toxicity to aquatic invertebrates

Description of key information

This study was conducted to determine the toxicity of Cycloaliphatic Epoxide resin ERL-4221 to Daphnia magna. This study was carried out under static test conditions in accordance with OECD Guideline 202. The test species were exposed to the following nominal test concentrations: Dilution water control and nominal 5.6, 10, 18, 32, 56, 100 and 180 mg/L, mean measured exposure concentrations were 5.2, 9.4, 16, 28, 57, 101 and 160 mg/L.  
After 48 hours, at the nominal concentration 32 mg/L and 56 mg/L observed immobility was 50 and 55% respectively, while at the higher concentrations of 100 mg/L and 180 mg/L, immobility was 5 and 20 % respectively. Therefore, to obtain a meaningful EC50 value, the 48 hour EC50 was calculated by exclusion of the highest two concentrations. However, the effects observed in this study do not satisfy the established criteria of a maximum effect of 65 % for calculation of an EC50.
 
Despite this, a reasonable judgement can be made from the data that the 48 hour EC50 value lies somewhere between 32 and 56 mg/L (where observed effects were 50 and 55 % respectively, so the value calculated using Stephan's method of 40 mg/L is appropriate.
 The NOEC (48-hour) was observed to be 10 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

40 mg/L

Additional information

A static acute toxicity study was carried out to determine the toxicity of Cycloaliphatic Epoxide resin ERL-4221 to Daphnia magna Straus. The study was conducted according to OECD Guideline 202.The 48 hour EC50 was calculated to be 40 mg/L, the corresponding NOEC was 10 mg/L.