Registration Dossier
Registration Dossier
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EC number: 200-526-2 | CAS number: 62-23-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: data published
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Publication in scientific French journal, some details on study available which are sufficient for classification
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicites comparees des acides nitrobenzoiques pour la Souris et la Rat
- Author:
- F. Caujolle, D. Caujolle, C. Moisand
- Year:
- 1 966
- Bibliographic source:
- Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales, Vol 160, p. 1097-1100
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- pre-guideline study
- Test type:
- other: no data available
Test material
- Reference substance name:
- 4-nitrobenzoic acid
- EC Number:
- 200-526-2
- EC Name:
- 4-nitrobenzoic acid
- Cas Number:
- 62-23-7
- Molecular formula:
- C7H5NO4
- IUPAC Name:
- 4-nitrobenzoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 to 220 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Details on oral exposure:
- concentration in vehicle: 10 %; sodium carbonate was added to achieve complete dissolution of the test substance. pH was adjusted to appr. 7.7 with hydrochloric acid.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 960 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- Effects on liver and spleen were traced.
Any other information on results incl. tables
No deaths were observed at 1410 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- In an acute oral toxicity study a LD50 of 1960 mg/kg bw was determined. The substance has therefore to be classified:
Regulation (EC) 1272/2008: Acute toxicity (oral) category 4, H302 Harmful if swallowed
Directive 67/548/EEC, Harmful, R 22 Harmful if swallowed
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