Registration Dossier
Registration Dossier
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EC number: 233-126-1 | CAS number: 10042-59-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment since reference is in a foreign language (adopted from OECD SIDS). Additionally, number of cells investigated was too few to correspond to scientific and regulatory requirements.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Barylak, IR and Kosaschuk, SJ
- Year:
- 1 988
- Bibliographic source:
- Tsitol. Genet. 22, 49-52; cited in OECD SIDS IUCLID data set of Isononyl alcohol (16.03.2006)
Materials and methods
- Principles of method if other than guideline:
- Each 10 rats were investigated, 1 ml test article/rat was orally administered by gavage as a 40% suspension in water. Preparation of bone marrow 48 h
after administration and microscopic analysis of 50 cells per animal. - GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- Nonan-1-ol
- EC Number:
- 249-048-6
- EC Name:
- Nonan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Nonylalcohol
- Analytical purity: not stated
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- - Vehicle(s)/solvent(s) used: water
- Concentration of test material in vehicle: 40% suspension - Details on exposure:
- 1 ml test article/rat was orally administered
- Duration of treatment / exposure:
- 48 h
- Frequency of treatment:
- no data
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2.26-12.8 mg/kg (1/5 LD50)
Basis:
no data
- No. of animals per sex per dose:
- 10 animals / dose
- Control animals:
- yes
Examinations
- Tissues and cell types examined:
- Preparation of bone marrow 48 h after administration and microscopic analysis of 50 cells per animal.
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Any other information on results incl. tables
3% of cells with aberration were observed, control group 0% of cells with aberrations.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
