Registration Dossier
Registration Dossier
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EC number: 214-317-9 | CAS number: 1120-71-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1964
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- INITIAL SUBMISSION: TOXICITY STUDIES OF 1,2-OXATHIOLANE,2,2-DIOXIDE WITH COVER LETTER DATED 09/01/92
- Author:
- OTS
- Year:
- 1 992
- Bibliographic source:
- Microfiche No. OTS0555330 , Doc ID 88-920009014
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2λ⁶-oxathiolane-2,2-dione
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: undiluted and 10% in water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10% - Doses:
- 50 - 3200 mg/kg bw
- No. of animals per sex per dose:
- - No of animals: 16 rats
- Sex: not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 100 - < 200 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality occured after 2 hours - 1 day.
- Clinical signs:
- other: Animals were moderately to very weak. They showed prostration, salivation, dark eyes, tremor, gasping, diarrhea and convulsions.
- Gross pathology:
- No abnormalities were found.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- CLP: Acute Oral 3, H301
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