Registration Dossier
Registration Dossier
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EC number: 231-820-9 | CAS number: 7757-82-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Remarks:
- old in vivo study
- Type of information:
- other: experimental data from literature data in read across
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Literature data
Data source
Reference
- Reference Type:
- publication
- Title:
- Magnesium chloride and potassium sulphate deicer.
- Author:
- Poe et al.
- Year:
- 2 013
- Bibliographic source:
- USP
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- Draize, H. H., et al., J. Pharm. Exp. Ther. 82:377-390 (1944)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Similar Substance 02
- IUPAC Name:
- Similar Substance 02
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Selected animals healthy and free from any evidence of ocular irritation and corneal abnormalities.
Test system
- Amount / concentration applied:
- 0.092 mg, applicated by syringe into the conjunctival sac of one eye.
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: flashlight equipped with high intensity bulb
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72h
- Score:
- ca. 0
- Max. score:
- 80
- Reversibility:
- other: not applicable
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 ,72h
- Score:
- ca. 0
- Max. score:
- 10
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48 ,72h
- Score:
- ca. 0
- Max. score:
- 20
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Tha substance is not irritating to the eye
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