Registration Dossier
Registration Dossier
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EC number: 278-780-9 | CAS number: 77881-13-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Jan 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only shortly reported GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 6 instead of 3 animals used
- GLP compliance:
- yes
Test material
- Reference substance name:
- 17 beta-cyano-17 alpha-hydroxy-4-androsten-3-on
- IUPAC Name:
- 17 beta-cyano-17 alpha-hydroxy-4-androsten-3-on
- Details on test material:
- - Name of test material (as cited in study report): ZK 74.804
- Batch No.: Ba 76700
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- physiological saline
- Controls:
- other: left side served as a control
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 5 days
- Number of animals:
- 3 males and 3 females
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- Body weight over 4 days was unchanged.
Applicant's summary and conclusion
- Executive summary:
500 mg of the test substance was semi-occlusively applied to the shaved intact skin of 3 male and 3 female rabbits for an exposure period of 4 h. Evaluation of skin irritation was made according to Draize.
In this skin irritation study AD-Cyanhydrin was not irritating to the skin.
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