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EC number: 203-157-5 | CAS number: 103-90-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Chronic toxicity of Paracetamol (acetaminophen) was evaluated using a fish (Oryzias latipes). The No-observable-effect-concentration (NOEC) value of acetaminophen in aquatic fish (Oryzias latipes) in a 90 days post fertilization study on various effects were reported as follows:
NOEC (90 dpf) = 95.0 mg/L (Survival)
LOEC (33 dpf) = 95.0 mg/L (Survival)
NOEC (19 dpf) = 95.0 mg/L (Survival)
NOEC (90 dpf) = 9.5 mg/L (Growth)
NOEC (90 dpf) = 9.5 mg/L (Relative organ weight)
NOEC (90 dpf) = 0.000095 to 9.5 mg/L (Vitellogenin)
NOEC (90 dpf) = 9.5 mg/L (Reproduction)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 95 mg/L
Additional information
Chronic toxicity of acetaminophen was evaluated using a fish (Oryzias latipes). The nominal concentrations selected for the study were 0, 0.000095, 0.00095, 0.0095, 0.095, 0.95, 9.5 and 95.0 mg/L. The effects on survival, growth, relative organ weight, vitellogenesis and the reproduction capacity of the fish were observed in a study. In the chronic fish toxicity test, significant reduction in juvenile survival was observed at 30 d post-hatch (dph) at 95 mg/L of acetaminophen. After the exposure to acetaminophen, vitellogenin levels tended to increase in male fish at 90 dph. In the eggs which were prenatally exposed to 9.5 mg/L of acetaminophen, reduced hatchability was observed.
Thus , the No-observable-effect-concentration (NOEC) value of acetaminophen in aquatic fish (Oryzias latipes) in a 90 days post fertilization study on various effects were reported as follows:
NOEC (90 dpf) = 95.0 mg/L (Survival)
LOEC (33 dpf) = 95.0 mg/L (Survival)
NOEC (19 dpf) = 95.0 mg/L (Survival)
NOEC (90 dpf) = 9.5 mg/L (Growth)
NOEC (90 dpf) = 9.5 mg/L (Relative organ weight)
NOEC (90 dpf) = 0.000095 to 9.5 mg/L (Vitellogenin)
NOEC (90 dpf) = 9.5 mg/L (Reproduction)
Our observations suggest however that ecological risks of Paracetamol (acetaminophen) is negligible at the concentrations currently found in the environment.
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