Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-607-0 | CAS number: 108-69-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Xylidine, BUA Stoffbericht 161
- Year:
- 1 994
- Bibliographic source:
- BUA, Beratergremium für umweltrelevante Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, S.Hirzel Verlag 1995
- Reference Type:
- publication
- Title:
- Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqeous solutions.
- Author:
- Vernot et al.
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 42, 417-423 (1977)
Materials and methods
Test guideline
- Guideline:
- other: no data
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,5-xylidine
- EC Number:
- 203-607-0
- EC Name:
- 3,5-xylidine
- Cas Number:
- 108-69-0
- Molecular formula:
- C8H11N
- IUPAC Name:
- 3,5-dimethylaniline
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 710 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 470 - <= 1 070
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- EU GHS
- Conclusions:
- The oral LD50 in rat was described as 710 mg/kg.
- Executive summary:
The test item was assessed in an standard acute toxicity test in rats following national stndard methods. The oral LD50 in rats was determined to be 710 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
