Registration Dossier
Registration Dossier
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EC number: 255-980-4 | CAS number: 42872-29-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study according to international guideline but not GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Episkin: reconstructed human epidermis
- Principles of method if other than guideline:
- EPISKIN Human Skin Model Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-(1-cyanoethyl)benzoyl chloride
- EC Number:
- 255-980-4
- EC Name:
- 3-(1-cyanoethyl)benzoyl chloride
- Cas Number:
- 42872-29-7
- Molecular formula:
- C10H8ClNO
- IUPAC Name:
- 3-(1-cyanoethyl)benzoyl chloride
- Details on test material:
- Batch: CFPPN-2C4.4
Constituent 1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: Not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CFPPN, an intermediate product of Ketoprofen synthesis, was non-irritant to the skin.
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