Registration Dossier
Registration Dossier
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EC number: 271-230-9 | CAS number: 68526-82-9 The high boiling residuum from the distillation of C7-11 alcohols.
Endpoint summary
Administrative data
Description of key information
Skin Irritation – minimal irritation for rabbits (OECD 404).
Eye Irritation – minimal irritation for rabbits (OECD 405).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The Heavy Oxo Fraction (Alkenes, C6-10, hydroformylation products, high-boiling, CAS#68526-82-9) is a mixture of components: A complex mixture of oxygenated hydrocarbons, primarily alcohols (C8 to C11) and aliphatic ethers (C16 to C22). All structures are branched and multi-isomeric. For the purposes of read across, data will be used from a commercial substance (Vammar D10, CAS #98072-31-2) that contains similar aliphatic ethers to Mixed HOF.
As assessed in dermal irritation studies, CAS # 98072 -31 -2 is transiently irritating to the skin. In a study utilizing an occluded patch exposure, the presence of erythema was noted within 4 hours of patch removal and remained present until at least seven days post exposure. The severity of the erythema induced by CAS # 98072 -31 -2 exposure ranged from very slight to severe during this time frame. However, upon removal, signs of irritation subside.
CAS # 98072 -31 -2 is also transiently irritating to the eye as assessed in rabbits. Redness was noted in all animals up to 24h post exposure and decreased steadily through 14 days post exposure.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
No classification for irritation is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.
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