Registration Dossier
Registration Dossier
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EC number: 939-238-3 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
According to REACH Regulation (Annex IX, 9.3.2, column II), test for bioaccumulation in aquatic species does not need to be conducted as the substance has a low potential for bioaccumulation.
Key value for chemical safety assessment
Additional information
Insolubility of the test substance and its rapid biotic degradation in water leads to negligibly low concentrations of Stearic acid, esters with methyl α-D-glucoside in the aquatic environment and thus to insignificant concentrations in aquatic organisms. Moreover, the uptake rate is likely to be much lower than the rate of the degradation processes, caused by the high molecular weight of the substance (461, 727, 994 and 1260 for mono-, di-, tri- and tetraester respectively) and spatial structure. ECETOC (2005) observed that molecular weight and size are factors that appear to be a reason for chemicals not to be readily taken up by fish (with consequently low bioconcentration factors), possibly because of steric hindrance of passage across cell membranes of respiratory organs.
The highest calculated bioaccumulation factor for one chemical species was log BCF = 3.2 resp. BCF = 1582 l/kg wet-wt.
In connection with readily biodegradability of the substance, it can be concluded that Stearic acid, esters with methyl α-D-glucoside is supposed to be not biologically available in the aquatic compartment and it can be assumed that bioaccumulation in aquatic species is negligible.
In addition, readily biodegradable chemicals generally have a higher probability of being metabolised. In a case of ester fission the Stearic acid, esters with methyl α-D-glucoside, consisting of α-methyl glucose and fatty acid chains, is likely to be rapidly metabolised in organisms.
Attendant to low solubility, readily biodegradability and low uptake of the substance, easy and rapid metabolism and depuration will lead to negligible concentrations in aquatic organisms and insignificant bioaccumulation.
This judgement is supported by the results of the short-term toxicity to fish study as well as a number of studies in mammals (including long-term studies in rat of the read across substance Isostearic acid, esters with methyl α-D-glucoside).
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