Registration Dossier
Registration Dossier
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EC number: 201-137-0 | CAS number: 78-73-9
Vapour pressure
Administrative data
Link to relevant study record(s)
Description of key information
Vapour pressure:
9.13 * E-10 Pa / 6.85 * E-12 mm Hg at 25 °C (Modified Grain Method (MPBPWIN v1.43), calculated for pure Choline carbonate)
2390.4 Pa at 25 °C (Modified Grain Method (MPBPWIN v1.43), calculated for 75 % aqueous solution of Choline carbonate via Raoult´s law)
Key value for chemical safety assessment
- Vapour pressure:
- 2 390.4 Pa
- at the temperature of:
- 25 °C
Additional information
The estimation of vapour pressure (as well as melting and boiling point) can be done by the MPBPWIN program (v 1.43) made available by the U.S. Environmental Protection Agency. This program requires just the input of the chemical structure of the desired compound by SMILES notation and is a scientifically accepted calculation method. The calculation is done by three different methods: Antoine, Modified Grain and Mackay, whereby the Modified Grain method is preferentially utilized. By taking this method into account and using an estimated boiling point of 459.56 °C, pure Choline carbonate has a vapour pressure of 9.13 * E-10 Pa / 6.85 * E-12 mm Hg at 25 °C.
As the substance is marketed as an 75 % aqueous solution, which is therefore the predominantly available form, it is justified out of scientific reasons and exposure considerations to regard Choline carbonate as aqueous solution. Hence, the vapour pressure was calculated using Raoult´s law and an experimental vapor pressure value for water of 3172.5 Pa at 25 °C, resulting in a calculated vapour pressure of 2390.4 Pa at 25 °C. This value is in the scientifically expected range as it is close to the vapour pressure of water.
The outcome of this study is considered reasonable, within the scientifically expected ranges and can be used for further risk assessment.
Due to the reliability of the results, as they were gained by a scientifically accepted calculation method, with regard to the predominantly existing form of Choline carbonate, i.e. a 75 % aqueous solution, the tonnage-driven requirements under REACH are fully met, no datagaps were identified and no further testing is required.
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