Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-oxopropyl)-, (1R,3S)-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23.02.1999-11.03.1999

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1999

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)

Test guideline 3

Qualifier:

according to guideline

Guideline:

other: US Environmental Protection Agency (EPA) Health Effects Test Guidelines OPPTS 870.1100, 1998

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

(1R,3S)-2,2-Dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid

Cas Number:

70223-33-5

Molecular formula:

C9H14O3

IUPAC Name:

(1R,3S)-2,2-Dimethyl-3-(2-oxopropyl)cyclopropanecarboxylic acid

Test material form:

solid: crystalline

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

3 male + 3 female. 8-12 weeks at the beginning of the study.
The animals were housed in groups of three by sex in solid-floor polypropylene cages gurnished with woodflakes.
With the exception of an overnight fast immediately before dosing and for approximately three to four hours after dosing, free access to mains drinking water and food.
The animal room was maintained at a temperature of 19-21ºC and relative humidity of 46 to 59%. The rate of air excange was approximately fifteen changes per hour and the lighting was controlled by a time swich to give twelve hours continuous light and twlve hours darkness.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 200 mg/ml
- Amount of vehicle (if gavage): 10 m/kg
Dose level: 2000 mg/kg

CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: The toxicity information available suggested that mortality was unlikely at the maximum dose level.

No. of animals per sex per dose:

3

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths

Clinical signs:

other: Signs of systemic toxicity noted were hunched posture, lethargy, pilo-erection, ataxia, decreased respiratory rate and laboured respiration, developing on the day of dosing and lasting up to five days after dosing.

Gross pathology:

No abnomalities were noted at necropsy.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

The substance has a acute oral LD50 > 2000 mg/kg. No deaths were found.