Registration Dossier
Registration Dossier
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EC number: 245-876-7 | CAS number: 23779-32-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (48h) > 100 mg/l, mobility Daphnia magna (OECD 202), RL1
Key value for chemical safety assessment
Additional information
There are no reliable data available for [3-(triethoxysilyl)propyl]urea (CAS 23779-32-0), therefore good quality data for the analogue, Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (116912-64-2), have been read across.
The related substance ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS 116912-64-2) is a multi-constituent substance, with the submission substance being one of the constituents.
Both substances share the same silanol hydrolysis product, 3-Ureidopropylsilanetriol.This study conducted according to OECD 202 and GLP in a static test over 48 hour using Daphnia magna as test organism (NOTOX, 2000e).
A limit test was performed with daphnia exposed to 100 mg/l and a blank-control in a static system and samples for analysis of actual exposure concentrations were taken at the start and the end of the limit test. The substance degraded rapidly within 48 h.
No immobility occurred during the 48-hour test period. Hence, the 48h-EC50 daphnia exposed to Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters was > 100 mg/l in static system. The high rate of hydrolytic degradation indicated little relevance for testing in a semi-static or flow-through system. Instead, the assessment of the toxic potential of exposure of daphnia to Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters was considered to be more realistic when exposure to degradation products was included.
The result is considered to be reliable. The test organisms were exposed primarily to the hydrolysis products of the substance.
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