Registration Dossier
Registration Dossier
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EC number: 230-786-2 | CAS number: 7320-37-8
Endpoint summary
Administrative data
Description of key information
The test substance Decyloxirane was irritating to the skin but not irritating to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion
The skin irritation potential of the test substance was evaluated in a study according to OECD Test Guideline 404 under GLP. The undiluted test substance was applied unchanged under occlusive conditions for 4 hours to the shaved skin of three Mol:Russian rabbits, which were observed for 21 days post application. Over the first three days, clear erythema and oedema were observed in all rabbits, which reversed fully within 21 days. The test substance was considered to be irritating to the skin.
Eye irritation
The eye irritation potential of the test substance was evaluated in a study according to OECD Test Guideline 405 under GLP conditions. The amount of 0.1 mL of the undiluted substance was applied unchanged for 24 hours to the eyes of three Mol:russian rabbits, which were observed for 7 days post application. Over the first three days minimal effects on the conjunctiva were observed which did fully reverse within 3 days. The test substance was not considered to be irritating to the eyes.
Justification for selection of skin irritation / corrosion endpoint:
Only study available
Justification for selection of eye irritation endpoint:
Only study available
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the irritating skin effects observed the test substance has to be classified as Skin Irrit. 2: H315: Causes skin irritation in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
As no eye irritating effects were observed, classification for eye irritation is not warranted in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
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