3-diethylaminophenol

Toxicity to aquatic algae and cyanobacteria

Description of key information

 

The effective concentration (EC50) value of 3-diethylaminophenol in green algae (Pseudokirchnerella subcapitata) in a 72 hr study on the basis of growth rate effect was estimated to be 15.0057 mg/L. But the BCF value of 3-diethylaminophenol reported was not >= 2000 as well as the substance was found to be rapidly degradable.Thus considering the CLP Criteria for aquatic classification of the substance , it is concluded that 3-diethylaminophenol could not exhibit short term toxicity to green algae (Pseudokirchnerella subcapitata) .

Key value for chemical safety assessment

EC50 for freshwater algae:

15.006 mg/L

Additional information

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 91-68-9 based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	EC50	15.0057 mg/l	growth rate	72 hrs	Pseudokirchnerella subcapitata	Predicted data for target chemical
2	EC50	10.75694 mg/l	Cell changes	72 hrs	Pseudokirchnerella subcapitata	Predicted data for target chemical
3	EC50	19.86983mg/l	growth inhibition	N/A	Pseudokirchnerella subcapitata	Data from DEPA
4	EC50	25.321mg/l	no data	96 hrs	green algae	Data from publication form ECOSAR

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in range of10.75694 to25.321 mg/l in 72 hrs to 96 hrs study.

But the BCF value of 3-diethylaminophenol reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering the CLP Criteria for aquatic classification of the substance , it is concluded that 3-diethylaminophenol does not exhibit toxicity to aquatic algae (green algae, Pseudokirchnerella subcapitata)