Registration Dossier
Registration Dossier
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EC number: 204-352-8 | CAS number: 119-80-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-dithiodi(benzoic acid)
- EC Number:
- 204-352-8
- EC Name:
- 2,2'-dithiodi(benzoic acid)
- Cas Number:
- 119-80-2
- Molecular formula:
- C14H10O4S2
- IUPAC Name:
- 2-[(2-carboxyphenyl)disulfanyl]benzoic acid
- Test material form:
- other: Solid
- Details on test material:
- The test material had a purity of 75.7%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Barriered Animal Breeding unit
- Age at study initiation: Young adults
- Weight at study initiation: 259-315g male, 215-233g female
- Fasting period before study: 24h
- Housing: suspended stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23
- Humidity (%): 40-70
- Air changes (per hr): 25-30
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- -dose volume: 10ml/kg
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- -observations: 2h, 3-7h post dose, daily up to day 15
-weighing: day before dosing, day of dosing, days 3, 6, 8, 15
-termination: all animals sacrifice on day 15 then subject to macroscopic post mortem examination
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Signs of diarrhoea were noted in 2 animals
- Gross pathology:
- There were no macroscopic abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- DTBA has an oral LD50 > 2000 mg/kg
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