Registration Dossier
Registration Dossier
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EC number: 206-982-9 | CAS number: 407-25-0
Endpoint summary
Administrative data
Description of key information
Skin and eye irritation/corrosion: Corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin corrosion potential of Trifluoroacetic anhydride (TFAH) was determined according to the OECD 435 (In vitro Membrane Barrier Test Method for Skin Corrosion). After the qualification screen and categorisation screen, 500 µl of the test item was evenly applied onto the top of the membrane disc, and the timer was started. The vial was observed for 3 minutes for any change in the CDS. Breakthrough was noted within 3 minutes of application therefore the remaining three discs were treated 1 day later. The vials were observed continuously until breakthrough of the test item had occurred. The first indication of breakthrough of the test item was detected as a change, either in colour or in physical appearance, in the CDS compared to the negative control. The positive (sulphuric acid 95 -98%) and negative (citric acid 10%) control were used and monitored until breakthrough had occured or for 60 minutes. The United Nations Packing Group Classification was determined on the basis of the Corrositex category assigned and mean breakthrough times. TFAH was assigned into Category 1. The mean breakthrough time of TFAH was 30 seconds.
Under the conditions of this test, TFAH is corrosive and is assigned to Packing Group 2. TFAH is classified as corrosif in category 1A,
H314, according to the CLP regulation.
Hence, in accordance with column 2 of REACH Annex VIII, the in vivo skin irritation study (required in section 8.1.1) and the in vivo eye irritation study (required in section 8.2.1) do not need to be conducted as TFAH is classified as corrosive according to Regulation (EC) No 1272/2006 including ATP1.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Harmonised classification:
No harmonised classification is available for Trifluoroacetic anhydride.
Self-classification proposed:
Trifluoroacetic anhydride is classified as:
- Skin Corr. 1A (H314, Cause severe skin burns and eye damage) according to the Regulation (EC) No 1272/2008 including ATP1
- Corrosive (C; R35) according to the Directive 67/548/EEC.
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