Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Additional information

Minute amounts of nicotinic acid are present in all living cells; greater amounts are found in liver, adrenal glands, milk, alfalfa, legumes and corn. If released to air, an estimated vapor pressure of 0.0125 Pa at 25 °C indicates nicotinic acid will exist in both the vapor and particulate phases in the atmosphere. If released to soil, nicotinic acid is expected to have very high mobility based upon estimated Koc values ranging from 0.531 to 0.911. The pKa of nicotinic acid is 4.75, indicating that this compound will primarily exist in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. If released into water, nicotinic acid is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. A pKa of 4.75 indicates nicotinic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process. An estimated BCF of 3.162 suggests that there is practically no potential for bioconcentration in aquatic organisms.