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EC number: 239-311-3 | CAS number: 15267-95-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Jul - 26 Sep 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: activated sludge taken from a WTP (Groß-Zimmern, Germany) treating domestic sewage
- Preparation of inoculum for exposure: the sludge was washed
- Initial cell/biomass concentration: 30 mg/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 25.1 - 25.5 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: reconstituted deionised water
- Test temperature: 21 - 22 °C
- pH: 7.6 - 7.9
- pH adjusted:no
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: Manometric test system
- Number of culture flasks/concentration: 2
- Measuring equipment: BSB/BOD-Sensor system
- Details of trap for CO2 and volatile organics if used: potassium hydroxide (45% aquaeous solution)
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes, 1 replicate
- Abiotic sterile control: yes, 1 replicate
- Toxicity control: yes, 1 replicate - Reference substance:
- aniline
- Remarks:
- Batch No.: K28124761
- Parameter:
- % degradation (O2 consumption)
- Value:
- 30 - 34
- Sampling time:
- 28 d
- Details on results:
- Degradation in toxicity control: 70% after 14 days and 68% after 28 days of incubation
- Results with reference substance:
- Degradation of Anilin: 82% after 14 days and 94% after 28 days of incubation.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- other: not readily biodegradable
- Conclusions:
- The substance was found not to be readily biodegradable (30-34%, O2 consumption) within 28 d according to OECD criteria.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification for grouping of substances provided in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Parameter:
- % degradation (O2 consumption)
- Value:
- 30 - 34
- Sampling time:
- 28 d
Referenceopen allclose all
Description of key information
Biodegradation in water, screening tests: 30-34 % in 28 days (OECD 301F)
Key value for chemical safety assessment
Additional information
There are no reliable ready biodegradation data available for (chloromethyl)triethoxysilane (CAS No. 15267-95-5), therefore good quality data for the structurally-related substance, Silane, (chloromethyl)dimethoxymethyl- (CAS No. 2212-11-5), have been read across. Both substances hydrolyse to structurally-related silanol hydrolysis products, (chloromethyl)silanetriol and (chloromethyl)methylsilanediol, the other hydrolysis products being methanol and ethanol, respectively, which are readily biodegradable (OECD, 2004a and b).
Both chloromethyl)triethoxysilane (CAS No. 15267-95-5) and silane, (chloromethyl)dimethoxymethyl- (CAS No. 2212-11-5) are within a wider analogue group, than the analogue group discussed in Section 1.4. Substances within this wider analogue group, in general, exhibit no evidence of any significant biodegradation once hydrolysis and subsequent biodegradation of alkoxy/acetoxy groups has been taken into account.
This wider analogue group for the ready biodegradability endpoint consists of a number of sub-classes of substances. However, read-across is carried out between substances with the same sub-class in most cases.
Table4.1.4presents ready biodegradation data within the analogue group (III-15) of chlorosilanes, siloxanes, silanes and alkoxysilanes etc, with chloroalkyl functional group(s) in side chain after any very rapid hydrolysis has been accounted for.
Both chloromethyl)triethoxysilane (CAS No. 15267-95-5) and silane,(chloromethyl)dimethoxymethyl- (CAS No. 2212-11-5) are members of this sub-class.
It is therefore considered valid to read-across the results for silane,(chloromethyl)dimethoxymethyl- to fill the data gap for the registered substance. Additional information is given in a supporting report (PFA, 2013f) attached in Section 13 of the IUCLID dossier.
Table 4.1.4: Ready biodegradation data available for substances within the relevant sub-class (III-15) of chemicals.
CAS |
Name |
Readily biodegradable? Yes/no |
Result: Biodegradation after 28 day |
Guideline |
Reliability |
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for |
002212-11-5 |
Silane, (chloromethyl)dimethoxymethyl- |
No |
30-34% |
OECD 301F |
1a |
-16 |
007787-93-1 |
Dichloro(3-chloropropyl)methylsilane |
No |
0% |
EC C4-C |
1a |
0 |
013501-76-3 |
(3-chloropropyl)diethoxymethylsilane |
No |
56% |
EC C4-A |
1a |
6 |
002530-87-2 |
3-chloropropyltrimethoxysilane |
No |
43% |
OECD 301 B |
1 |
-7 |
005089-70-3 |
(3-chloropropyl)triethoxysilane |
No |
46% |
EC C4-C |
1a |
-21 |
002344-80-1 |
Chloromethyltrimethylsilane |
No |
6% |
OECD 301D |
1a |
6 |
In the study 30–34 % biodegradation was observed in 28 days. The study was conducted according to OECD guideline 301F and is considered reliable (IBACON, 2002). This is selected as the key study.
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