Registration Dossier
Registration Dossier
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EC number: 201-627-4 | CAS number: 85-73-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- GISAAA Gigiena i Sanitariya
- Author:
- Mezhdunarodnaya Kniga
- Year:
- 1 993
- Bibliographic source:
- (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : TH8575000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances);GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(12),9,1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phthalylsulfathiazole
- EC Number:
- 201-627-4
- EC Name:
- Phthalylsulfathiazole
- Cas Number:
- 85-73-4
- Molecular formula:
- C17H13N3O5S2
- IUPAC Name:
- 2-({4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}carbamoyl)benzoic acid
- Test material form:
- other: amorphous
- Details on test material:
- - Name of test material : phthalylsulfathiazole
- Molecular formula : C17H13N3O5S2
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 30 days
- Frequency of treatment:
- intermittent
Doses / concentrations
- Remarks:
- Doses / Concentrations:
12900 mg/kg/30D (intermittent)
Basis:
no data
Results and discussion
Results of examinations
- Details on results:
- Gastrointestinal - changes in structure or function of esophagus
Effect levels
- Dose descriptor:
- other: TDL0
- Effect level:
- 12 900 other: mg/kg/30D (intermittent)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
Applicant's summary and conclusion
- Conclusions:
- TDLo - Lowest published toxic dose for phthalylsulfathiazole in rats was reported as 12900 mg/kg/30D (intermittent)
- Executive summary:
TDLo - Lowest published toxic dose for phthalylsulfathiazole in rats was reported as 12900 mg/kg/30D (intermittent)
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