Registration Dossier
Registration Dossier
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EC number: 291-378-8 | CAS number: 90388-00-4
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Accumulation of Heptadecanol N in organisms is unlikely.
Key value for chemical safety assessment
Additional information
There are no study data on bioaccumulation of the registered substance (Heptadecanol N, CAS 90388-00-4) available. The registered substance represents a mixture of branched and linear alcohols with a carbon chain length of 17. Higher alcohols are characterized by log Kow values well above 3, which indicate a high bioaccumulation potential. In case of the registered substance the log Kow was calculated to be 7.23. However the low water solubility (< 1 mg/L) results in a low bioavailability. Nevertheless, if such alcohols will cross biological membranes rapidly metabolisation can be expected, since the biotransformation of alcohols to carboxylic acids is ubiquitous in plants and animals.
The biotransformation has been specifically identified in a number of aquatic and terrestrial species. One of the available studies, which was conducted for branched alcohols with a chain length of 10, 12 and 13 carbons [de Wolf and Parkerton, 1999], is used as read across for the registered substance. This read across study was carried out according to OECD guideline 305, with the rainbow trout (Oncorhynchus mykiss) as test organism. Based on the test results (BCF < 100) bioaccumulation of the tested alcohols in aquatic species is not expected. The longer carbon chain length of the registered substance increase the duration time for the metabolism in biota and may influence slightly the bioaccumulation potential. Counteractive the lower water solubility reduces the bioavailability of the C17 alcohols. To take all the described information into account it can be concluded that accumulation of Heptadecanol N in organisms is unlikely.
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