Registration Dossier
Registration Dossier
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EC number: 232-007-1 | CAS number: 7783-54-2
Endpoint summary
Administrative data
Description of key information
In the acute inhalation toxicity test, Deichmann and Gerarde stated that NF3 is a pulmonary irritant; however classical clinical signs of respiratory irritation, i.e. tachypnea and gasping are likely to be due to anoxia resulting from methaemoglobin formation, rather than direct respiratory irritation. Therefore, no specific testing for respiratory irritation is considered necessary.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study technically not feasible
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Whilst both skin and eye irritation data for NF3 are lacking, no significant signs of skin irritation have been reported in the animal experiments. The majority of animal experiments have reported that NF3 causes clinical signs of eye irritation, irrespective of the species. However, the eye irritation occured during exposure only and did not persist following withdrawal of exposure. In the acute inhalation toxicity test, Deichmann and Gerarde stated that NF3 is a pulmonary irritant; however classical clinical signs of respiratory irritation, i.e. tachypnea and gasping are likely to be due to anoxia resulting from methaemoglobin formation, rather than direct respiratory irritation. Therefore, no specific testing for respiratory irritation is considered necessary.
Justification for selection of skin irritation / corrosion endpoint:
As nitrogen trifluoride is a gas, the dermal route of exposure is not relevant
Justification for selection of eye irritation endpoint:
This study does not need to be conducted as the substance is a gas. Evidence from whole body exposure studies document clincial signs of eye irritation during exposure only, which did not persist following withdrawal from exposure.
Justification for classification or non-classification
Skin irritation: no classification required.
Eye irritation: no classification required.
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