Registration Dossier
Registration Dossier
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EC number: 213-668-5 | CAS number: 999-97-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data waiving: Data from handbook or collection of data
Data source
Reference
- Title:
- SIAM 29, 20-22 October 2009, SIDS INITIAL ASSESSMENT PROFILE
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- In bacterial reverse mutation assays with Salmonella typhimurium and E. coli, HMDZ was negative both with and without metabolic activation. Mammalian gene mutation assays with L5178Y mouse lymphoma cells were negative both with and without metabolic activation. An in vitro chromosomal aberrations test using HMDZ was negative both with and without metabolic activation. Based on these results, HMDZ is considered to be non-genotoxic in vitro
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