Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-594-9 | CAS number: 97-61-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- The Lipids, Their Chemistry and Biochemistry. Vol III
- Author:
- Deuel, H.J. (ed.):
- Year:
- 1 957
- Bibliographic source:
- Wiley Interscience, N.Y., 1957 (cited in WHO/IPCS 1998)
- Report date:
- 1957
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylvaleric acid
- EC Number:
- 202-594-9
- EC Name:
- 2-methylvaleric acid
- Cas Number:
- 97-61-0
- Molecular formula:
- C6H12O2
- IUPAC Name:
- 2-methylpentanoic acid
Constituent 1
Test animals
- Species:
- rabbit
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
2-Methylvaleric acid, an alpha-substituted acid, undergoes ß-oxidation in the longer branched-chain followed by cleavage to yield two propionyl CoA fragments. In rabbits, 2-methylvaleric acid is converted to propionyl CoA which is completely metabolised (Deuel, 1957).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
