Registration Dossier
Registration Dossier
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EC number: 413-110-2 | CAS number: 135861-56-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Body responsible for the test
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EEC, C3
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Body responsible for the test
- IUPAC Name:
- Body responsible for the test
- Test material form:
- other: Solution
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.08 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- biomass
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.08 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 0.08 mg/L
- Nominal / measured:
- meas. (TWA)
- Basis for effect:
- biomass
Any other information on results incl. tables
%Concentration loss over test: 21
ErC50 (0 to 24h) 0.080 mg/L.
Water hardness is not measured.
The test concentration of 0.10 mg/L was the highest attainable test concentration due to the limited solubility of the test material in water and auxiliary solvent, and having due regards for the amount of auxiliary solvent permitted in the test under the OECD Guidelines.
Analysis of the test solutions at 0 and 72 hours showed a marked decline in test concentrations and so it was considered justifiable to bas the results on the time-weighted mean measured test concentration also. Given that pre-study stability analysis showed the test material to be stable in the culture medium used over the study period, the decline in measured test concentrations is considered to be due to adsorption to the algal cells. Adsorption was not a factor in the pre-study analyses as no algal cells were present.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Due to its low water solubility, the test substance is not considered to be toxic to aquatic algae or cyanobacteria under the condition of the test.
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