Registration Dossier
Registration Dossier
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EC number: 692-514-2 | CAS number: 133047-57-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,10-bis[(2-aminopropyl)amino]-6,13-dichloro-5,12-dioxa-7,14-diazapentacene-4,11-disulfonic acid
- EC Number:
- 692-514-2
- Cas Number:
- 133047-57-1
- Molecular formula:
- C24H24Cl2N6O8S2
- IUPAC Name:
- 3,10-bis[(2-aminopropyl)amino]-6,13-dichloro-5,12-dioxa-7,14-diazapentacene-4,11-disulfonic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 3 males
3 females
Results and discussion
Any other information on results incl. tables
A group of three male and three female Hanlbm: WIST (SPF) rats was treated with the test substance at 2000 mg/kg by oral gavage. The test article was suspended in vehicle (bi-distilled water) at a concentration of 0.2 g/ml and administered at a volume of 10 ml/kg. Four times during day 1 and once daily during days 2-15 the animals were examined for clinical signs.
Mortality/viability were recorded together with clinical signs at the same time intervals.
Body weights were recorded on day 1 prior to administration and on days 8 and 15.
All animals were necropsied and examined macroscopically.
No deaths occurred during the study.
No clinical signs of toxicity were observed during the observation period.
The body weight of the animals was within the range of physiological variability known for rats
of this strain and age.
No macroscopic organ findings were observed at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The mean lethal dose of the test substance after single oral administration to rats of both sexes,
observed over a period of 14 days, could not be estimated, because no death occurred.
LD50 : greater than 2000 mg/kg V - Executive summary:
LD50 : greater than 2000 mg/kg V
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