Bottom residues resulting from the synthesis of propylene oxide and styrene from epoxidation of propylene with ethylbenzene hydroperoxide

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Study period:

24.02.2011

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study according to OECD 105 but not under GLP conditions

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

not applicable

GLP compliance:

no

Type of method:

flask method

Test material

Test material information

Constituent 1

Reference substance name:

Bottom product of propylene oxide and styrene production

IUPAC Name:

Bottom product of propylene oxide and styrene production

Details on test material:

- Name of test material (as cited in study report): KORE grade V
- Substance type: UVCB
- Physical state: Brown viscous liquid
- Stability under test conditions: months
- Storage condition of test material: room temperature

Results and discussion

Any other information on results incl. tables

Method

 

A test was performed to determine a value of the water solubility and the effect of different loads.

 

Therefore three Erlenmeyer flasks were equipped with magnetic stir bars and 50 ml double distilled water was added. Each of the three Erlenmeyer flasks was prepared with different loads. 0.5 g, 1.0 g, and 2.0 g of the test item “KORE grade V” were added. The test vessels were stirred for approximately 8 hours and afterwards they were standing still to allow the substance to settle down for approx. 16 hours. The temperature was 20 °C ± 1 °C during the test period.

 

After settle down time a specimen of each vessel was taken with steel needle and glass syring. These specimens were diluted 1 to 100 to prepare the specimens for the analytical method. The total organic carbon concentration was determined by means of TOC.

Results

 

The results were determined by measurement of the TOC (Total Organic Carbon) dissolved in the aqueous phase.

The carbon part of the test item is determined by an elementary analysis. 82.53 % of the test item consists of carbon.

 

Table 1:Influence of the load

Amount of test item	Diluted carbon concentration	Dilution factor	Undiluted carbon concentration	Test item concentration
[g]	[mg/l]	[1/x]	[g/l]	[g/l]
0.5	22.00	100	2.20	2.67
1	35.87	100	3.59	4.35
2	52.78	100	5.28	6.40

 

The three different loads show a correlation between the loaded amount of the test item and the measured concentration of the aqueous phase. Higher concentrations of the test item effects a higher amount of the soluble part of the test item in the aqueous phase.

 

Discussion

 

The effect of correlation between higher loads to higher concentration of soluble compounds is attributed to the increase of absolute amount of the soluble compounds. It is possible that the more easily soluble compounds act as solubilizer for the not readily soluble substances. Therefore a determination of the water solubility of the test item will be influenced by some easily soluble parts of the complex composition of test item. These easily soluble parts have a disproportional influence.

 

All together a determination of the water solubility according to OECD 105 is not possible.

 

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): other: no result
no result

Executive summary:

The effect of correlation between higher loads to higher concentration of soluble compounds is attributed to the increase of absolute amount of the soluble compounds. It is possible that the more easily soluble compounds act as solubilizer for the not readily soluble substances. Therefore a determination of the water solubility of the test item will be influenced by some easily soluble parts of the complex composition of test item. These easily soluble parts have a disproportional influence.

 

All together a determination of the water solubility according to OECD 105 is not possible.