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EC number: 223-622-6 | CAS number: 3982-91-0
Endpoint summary
Administrative data
Description of key information
The LC50 (rat, 4h): 140 mg/m³
The LD50 (rat, oral) 750 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: most important information is available
- Principles of method if other than guideline:
- Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Body weight 180-200 g
Fasting before dosing - Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Details on oral exposure:
- Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil.
- Doses:
- Eight or nine dose levels (no further data)
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil. After a 14-day observation period the LD50 was calculated
- Statistics:
- LD50 was calcuclated according to Bliss (1935) and according to Trevan (1927)
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 750 mg/kg bw
- Based on:
- other: calculated according to Trevan (1927) Proc Roy Soc London 101, 483, 712
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 700
- Based on:
- other: calculated according to Bliss (1935) Ann Appl Biol 22134-167
- Mortality:
- no details given
- Clinical signs:
- no details given
- Body weight:
- At the beginning 180-200 g , no further data
- Gross pathology:
- no data
- Other findings:
- no data
- Executive summary:
Groups of 10 fasted rats of each sex were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated: LD50(rat) 750 mg/kg bw.
Reference
no data
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 750 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described sufficient for evaluation
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 140 mg/m³
Additional information
Oral
Groups of 10 fasted male and female Sprague Dawley rats or 10 fasted male and female Wistar rats were dosed by gavage at eight or nine dose levels of thiophosphoryl trichloride in vegetable oil (no further details). After a 14-day observation period the LD50 was calculated for each species with 2 different methods. The resulting LD50 ranged between 700 and 750 mg/kg bw for Sprague Dawley rats and for Wistar tats between 750 and 800 mg/kg bw (Calosi-Esca 1984). Based on these data LD50 (rat, oral) = 750 mg/kg bw is relevant for further considerations.
Inhalation
In none of the available publications considering acute inhalation toxicity detailed description of the method used is available. Chruscielka 1971 and Marhold 1972 reported at least a 4-hour exposure time resulting in LC50 value of 0.14 mg/l for rats and 0.63 mg/l for guinea pig. Galushka published LC50 values for rats, mice and guinea pig of 0.53 mg/l, 0.63 mg/l and 0.4 mg/l , respectively, without details and the National Defense Research Committee cited by RTECS gives a LCL0-value of 3 mg/l for a 10 min exposure. Based on these data the LC50 (rat, 4h) of 0.14 mg/l (140 mg/m³) is chosen on a weight of evidence consideration as relevant.
Dermal
There are no valid data available for thiophosphoryl trichloride. According Annex VI to Regulation (EC) no 1272/2008 no legal classification exists for dermal toxicity regarding the hydrolysis products of thiophosphoryl trichloride.
Justification for selection of acute toxicity – oral endpoint
The most reliable study was used as key study and for classification
Justification for classification or non-classification
Oral
Based on the data above it is proposed to group thiophosphoryl trichloride in category 4 for acute oral exposure (H302).
Inhalation
Based on the above discussed information it is proposed to group thiophosphoryl trichloride in category 1 for acute inhalation exposure (H330).
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