Registration Dossier
Registration Dossier
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EC number: 691-746-1 | CAS number: 220380-44-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- ca. 55% active substance (moist; water)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Number of animals or in vitro replicates:
- 1 male
2 females
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24,48,72 h
- Score:
- 1.67
Any other information on results incl. tables
The primary irritation potential of the test article was investigated by instillation of 0.1 g into
one eye of each of three young adult New Zealand White rabbits. The treated eyes were not
rinsed after application. Scoring of irritation effects was performed approximately 1, 24, 48
and 72 hours after test article application. The scores of each animal at the following reading
times (24,48 and 72 hours) were used in calculating the respective mean values for each type
of lesion.
The primary irritation score was calculated by totalling the individual cumulative scores at 24,
48 and 72 hours and then dividing the resulting total by the number of data points. The
primary irritation score was 1.67 (max. 13). Moderate reddening (including hyperemia of the
scleral blood vessels) and slight swelling of the conjunctivae, as well as slight watery
discharge were observed in all animals 24 hours after treatment. All signs of irritation were
reversible after 72 hours.
No staining of the treated eyes by the test article was observed.
No corrosion was observed at any of the measuring intervals.
Based upon the referred classification criteria (EEC Commission Directive 93/21/EEC of
April 27, 1993), FAT 93'463/A is considered to be "not irritating" to the eye.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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