Registration Dossier
Registration Dossier
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EC number: 217-420-7 | CAS number: 1843-03-4
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Read across to structural analogue, EC Name; 6,6’-di-tert-butyl-4,4’-butylidenedi-m-cresol; CAS No. 85 -60 -9, treatment by oral gavage in male and female Wistar Han rats revealed no parental, reproductive, or developmental toxicity up to 1000 mg/kg body weight/day.
Based on these results, a parental, reproductive and developmental No Observed Adverse Effect Level (NOAEL) of at least 1000 mg/kg/day was derived.
Short description of key information:
Parental, reproductive and developmental No Observed Adverse Effect Level (NOAEL) of at least 1000 mg/kg/day was derived.
Justification for selection of Effect on fertility via oral route:
Effect level determined in accordance with OECD guideline no. 421.
Justification for classification or non-classification
Based on the results of a close structural analogue the substance does not trigger any of the requirements for classification. The registered susbstance is therefore not classified.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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