Registration Dossier
Registration Dossier
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EC number: 202-810-1 | CAS number: 100-01-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Year:
- 1 983
- Bibliographic source:
- TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,128,1983
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY7000000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,128,1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitroaniline
- EC Number:
- 202-810-1
- EC Name:
- 4-nitroaniline
- Cas Number:
- 100-01-6
- Molecular formula:
- C6H6N2O2
- IUPAC Name:
- 4-nitroaniline
- Details on test material:
- - Name of test material (as cited in study report): 4-nitroaniline
- Substance type: Organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 90D (intermittent)
- Control animals:
- not specified
Results and discussion
Results of examinations
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- changes in spleen Blood - changes in other cell count (unspecified)
Effect levels
- Dose descriptor:
- LOEL
- Effect level:
- 2 700 mg/kg bw (total dose)
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: effects :- Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in spleen Blood - changes in other cell count (unspecified)
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Repeated dose toxicity LOEL (TDLo - Lowest published toxic dose) of 4-nitroaniline to rodent (Rat) by the oral route was observed at dose concentration of 2700 mg/kg.This indicates that 4-nitroaniline shall not exhibit toxic effects to rat by the oral route below the above mentioned dose.
- Executive summary:
Repeated dose toxicity LOEL (TDLo - Lowest published toxic dose) of 4-nitroaniline to Rodent - rat by the oral route was observed at dose concentration of 2700 mg/kg.This indicates that 4-nitroaniline shall not exhibit toxic effects to rat by the oral route below the above mentioned dose.
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